Baclofen Induced Encephalopathy in Patients with Chronic Kidney Disease
Published: September 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/44729.13998
Alok Kumar, Dorchhom Khrime, Nitin Bansal, Saurabh Agarwal, Utkarsh Sharma
1. Associate Professor, Department of Nephrology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
2. Professor, Department of Medicine, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
3. Professor, Department of Medicine, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
4. Associate Professor, Department of Medicine, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
5. Professor and Head, Department of Paediatrics, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
Correspondence
Alok Kumar,
Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, Uttarakhand, India.
E-mail: alokkraj@rediffmail.com
Hiccups are manifestation of uremic syndrome. Baclofen had been used in uremic hiccups, but its usage has been described in literature with development of neurotoxicity in patients with renal failure. The case series reports three patients of Chronic Kidney Disease (CKD) that were on haemodialysis. All of them had intractable hiccups, for which Baclofen was administered. They developed encephalopathy within 24-48 hours of ingestion of Baclofen. The drug was discontinued and the patients improved within 36-48 hours. They were finally discharged with no residual neurological deficit.
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